Journal article
Long-term effects of combined neonatal and adolescent stress on brain-derived neurotrophic factor and dopamine receptor expression in the rat forebrain
RA Hill, S Kiss Von Soly, U Ratnayake, M Klug, MD Binder, AJ Hannan, M van den Buuse
Biochimica Et Biophysica Acta Molecular Basis of Disease | ELSEVIER | Published : 2014
Abstract
Altered brain-derived neurotrophic factor (BDNF) signalling and dopaminergic neurotransmission have been shown in the forebrain in schizophrenia. The 'two hit' hypothesis proposes that two major disruptions during development are involved in the pathophysiology of this illness. We therefore used a 'two hit' rat model of combined neonatal and young-adult stress to assess effects on BDNF signalling and dopamine receptor expression. Wistar rats were exposed to neonatal maternal separation (MS) stress and/or adolescent/young-adult corticosterone (CORT) treatment. At adulthood the medial prefrontal cortex (mPFC), caudate putamen (CPu) and nucleus accumbens (NAc) were analysed by qPCR and Western ..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
This work was supported by a National Health and Medical Research Council (NHMRC) project grant #566879. RH was supported by a NHMRC early career training fellowship. MvdB was supported by a NHMRC Senior Research Fellowship. AJH is an Australian Research Council (ARC) Future Fellow (FT3). MK was supported by a Ph.D. scholarship from Swinburne University, Hawthorne, Melbourne. The Florey Institute of Neuroscience and Mental Health acknowledges the strong support from the Victorian Government and in particular the funding from the Operational Infrastructure Support Grant. These funding sources had no influence over the direction of the research or the content of this paper.